The wide acceptance that Climate Change (CC) is a reality, often taking extreme forms, has led to the development of strategies to mitigate climate change and the need to adapt to the new climate conditions. Greece has already developed a National Strategy for Adaptation to Climate Change (NSACC), which has started to be implemented in 2016 in the 13 regions of the state by implementing relevant projects. The Primary Sector of Agriculture (PSA) is one of the most vulnerable sectors to CC in Greece. This analysis describes the main points of the national strategy for mitigation and adaptation, focusing on the adaptation strategy for the PSA. Most of the information included in the analysis comes from a multidisciplinary study organized by the Bank of Greece (BoG), which was used as a guide for the formulation of the NSACC. The analysis includes a comprehensive summary of the PSA adaptation policy to CC, an assessment of climate evolution in Greece with emphasis on the characteristics related to the PSA, estimations of the CC impact on plant and animal production, and the whole organization of the national effort for adaptation to CC. The entire organization of the work followed the framework of the BoG study and the methodologies used in this paper.