The Mediterranean Basin’s diverse climates and ecosystems have shaped a rich botanical heritage through centuries of selective cultivation, resulting in a wide array of horticultural plants with valuable therapeutic properties. The use of horticultural food plants as herbal remedies has become an integral part of traditional medicine in this geographical context. The present review aims to highlight the use of horticultural food plants (HFPs) in the context of traditional herbal medicine in the countries of the Mediterranean Basin and explore their traditional uses and therapeutic properties. A comprehensive ethnobotanical literature search was conducted on the food plants used as herbal medicine in the Mediterranean region using existing online scientific databases. Based on the literature review, 64 taxa used as medicinal plants by traditional users in the Mediterranean Basin were documented. Overall, horticultural plants are used in Mediterranean countries to treat a total of 573 ailments. Italy has the highest number of use reports (998), followed by Morocco (281) and Spain (193). Apiaceae (11 taxa), Cucurbitaceae (9 taxa), and Brassicaceae (8 taxa) are the most frequently cited families. The genus Allium is the most abundant in species (5).
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